A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation

A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation

Stimulator of interferon genes (STING) is crucial for the kind I interferon response induced by microbial DNA from virus or self-DNA from mitochondria/nuclei. In response to emergence of such DNAs within the cytosol, STING translocates from the endoplasmic reticulum to the Golgi, and prompts TANK-binding kinase 1 (TBK1) on the trans-Golgi community (TGN). Activated TBK1 […]