New monoclonal antibodies that recognize an unglycosylated, conserved, extracellular region of CD44 in vitro and in vivo, and can block tumorigenesis

New monoclonal antibodies that recognize an unglycosylated, conserved, extracellular region of CD44 in vitro and in vivo, and can block tumorigenesis

CD44 is a transmembrane glycoprotein that binds to hyaluronic acid, performs roles in various mobile processes and is expressed in quite a lot of cell sorts. It’s up-regulated in stem cells and most cancers. Anti-CD44 monoclonal antibodies have an effect on cell motility and aggregation, and repress tumorigenesis and metastasis. Right here we describe 4 […]