The anti-epithelial cell adhesion molecule (EpCAM) monoclonal antibody EpMab-16 exerts antitumor exercise in a mouse mannequin of colorectal adenocarcinoma
Concentrating on EpCAM by a Bispecific Trifunctional Antibody Exerts Profound Cytotoxic Efficacy in Germ Cell Tumor Cell Traces
In distinction, tumor cell lysis mediated by both immune cell subset alone is influenced by floor density of the goal antigen. Within the CHC line JAR, NK cell-dependent cytotoxicity dominates, which can be attributed to differential floor expression of immunomodulatory proteins equivalent to MHC-I, CD24, and Fas receptors on CHC and EC. In view of redirecting T cell remedy mediated by bispecific antibodies, such variations in GCT immunophenotype doubtlessly favoring immune escape are value additional investigation.