Linker engineering in anti-TAG-72 antibody fragments optimizes biophysical properties, serum half-life, and high-specificity tumor imaging.

Linker engineering in anti-TAG-72 antibody fragments optimizes biophysical properties, serum half-life, and high-specificity tumor imaging.

Antibody (Ab) fragments have nice medical potential as most cancers therapeutics and diagnostics. Their small measurement permits for quick clearance from blood, low immunoreactivity, higher tumor penetration, and less complicated engineering and manufacturing. The smallest fragment derived from a full-length IgG that retains binding to its antigen, the single-chain variable fragment (scFV), is engineered by […]