What is the state of the art of computer vision-assisted cytology? A Systematic Literature Review

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Cytology is a low-cost and non-invasive diagnostic process employed to help the prognosis of a broad vary of pathologies. Cells are harvested from tissues by aspiration or scraping, and it’s nonetheless predominantly carried out manually by medical or laboratory professionals extensively skilled for this function. It’s a time-consuming and repetitive course of the place many diagnostic standards are subjective and susceptible to human interpretation. Laptop Imaginative and prescient applied sciences, by mechanically producing quantitative and goal descriptions of examinations’ contents, might help reduce the probabilities of misdiagnoses and shorten the time required for evaluation.

To determine the state-of-art of laptop imaginative and prescient strategies presently utilized to cytology, we performed a Systematic Literature Assessment, trying to find approaches for the segmentation, detection, quantification, and classification of cells and organelles utilizing laptop imaginative and prescient on cytology slides.  After making use of the inclusion/exclusion standards, 157 papers remained, which we analyzed to construct an image of the tendencies and issues current on this analysis space, highlighting the pc imaginative and prescient strategies, staining strategies, analysis metrics, and the supply of the used datasets and laptop code.

Because of this, we recognized that probably the most used strategies within the analyzed works are deep learning-based (70 papers), whereas fewer works make use of basic laptop imaginative and prescient solely (101 papers). Essentially the most recurrent metric used for classification and object detection was the accuracy (33 papers and 5 papers), whereas for segmentation it was the Cube Similarity Coefficient (38 papers). Concerning staining strategies, Papanicolaou was probably the most employed one (130 papers), adopted by H&E (20 papers) and Feulgen (5 papers).

Twelve of the datasets used within the papers are publicly out there, with the DTU/Herlev dataset being probably the most used one. We conclude that there nonetheless is an absence of high-quality datasets for a lot of sorts of stains and a lot of the works will not be mature sufficient to be utilized in a day by day scientific diagnostic routine. We additionally recognized a rising tendency in direction of adopting deep learning-based approaches because the strategies of selection.

Exploring Employees Turnover, Burnout and Resilience in Cytology Reference Laboratories: A Workforce Qualitative Research

The precise goals of the examine are to analyze cytology laboratory employees turnover within the context of office stressors and burnout and to discover qualities related to lengthy profession tenure, in an effort to facilitate the event of future office intervention packages. A fundamental interpretive qualitative examine strategy with semi-structured interviews was performed and analyzed utilizing a directed and standard content material evaluation. Seven individuals who had left giant cytology reference laboratories had been purposively sampled to interview about their expertise of leaving the cytology reference laboratories.
Standard content material evaluation was used to inductively generate themes and deductive content material evaluation was performed with classes from the Transactional Mannequin of Stress and Coping or TMSC (ie: stress appraisal and coping type).  Three principal themes had been discerned from the interviews; considerations in regards to the cytology office, causes for selecting to go away and methods for dealing with stress. Demand for productiveness was probably the most generally cited concern amongst cytotechnologists, adopted by work-life stability and musculoskeletal pressure associated to microscopic screening. The highest motive given for folks selecting to go away the business laboratories was the shortage of work-life stability and the second was the shortage {of professional} challenges and development alternatives.
Individuals with longer job tenure who skilled a promotion described dealing with job stress as extra optimistic and downside targeted. Alternatives exist inside giant business laboratories round enhancing work atmosphere to cut back office burnout and turnover. Our findings revealed that the most typical stressors encountered at giant business laboratories are productiveness calls for adopted by work-related musculoskeletal strains related to microscopic screening.
What is the state of the art of computer vision-assisted cytology? A Systematic Literature Review

Moreover, the highest causes given for folks leaving giant reference laboratories had been the shortage of work-life stability and the paucity {of professional} challenges and development alternatives. Moreover, the examine discovered that cytotechnologists with longer skilled tenure at business laboratories gave the impression to be extra optimistic and problem-focused of their approaches with workplace-related stress and points. Two-Liner Abstract. We analyzed papers revealed within the final four years. The preliminary search was executed in September 2020 and resulted in 431 articles.

Positive needle aspiration cytology of a myxoid adrenocortical adenoma. A case report

The myxoid variant of adrenocortical (AC) tumors is characterised by peculiar histologic options that differ from typical ones. It reveals a distinguished myxoid stromal element and consists of small cells with delicate atypia organized in cords, pseudoglandular buildings and microcysts. Reflecting the rarity of this variant, only a few cytologic descriptions can be found. We describe one case in a 41-year-old lady with a earlier prognosis of breast carcinoma and BRCA1 mutation.

Throughout follow-up controls, an adrenal tumor was found. Positive needle aspiration cytology and Tru-Minimize biopsies had been carried out concurrently. Smears confirmed quite a few teams of cohesive cells of intermediate to small dimension. Inside the largest teams, aggregates of myxoid metachromatic materials had been evident. This myxoid materials is also noticed as remoted acellular fragments. Whereas the cytoplasm of most tumoral cells was homogenously stained some confirmed small vacuoles. Histologically, the tumor grew, forming anastomosing cords, separated by myxoid materials that decided microcystic areas.

ELISA kit for Human Creatinine (Cr)
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ELISA kit for Human Creatinine (Cr)
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Description: Quantitative sandwich ELISA for measuring Human Creatinine (Cr) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

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Creatinine [BTG]
DAGA-186G 500ug
EUR 1425.6

Creatinine-HRP
80-1133 500 ul
EUR 159.6
Description: Creatinine Conjugate for use in immunoassays

Creatinine-HRP
DAG-CL005 500 μl
EUR 1248

Creatinine(N) [HRP]
DAG1075 0.5ml
EUR 1014

ELISA kit for Human Urinary creatinine (UCR)
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Description: Quantitative sandwich ELISA for measuring Human Urinary creatinine (UCR) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Urinary creatinine (UCR)
KTE62727-5platesof96wells 5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Human Urinary creatinine (UCR) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Urinary creatinine (UCR)
KTE62727-96T 96T
EUR 686.4
Description: Quantitative sandwich ELISA for measuring Human Urinary creatinine (UCR) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Creatinine N-HRP
80-1132 500 ul
EUR 970.8
Description: Creatinine N Conjugate for use in immunoassays

2‐AMINO ACETAMIDE HYDROCHLORIDE (GLYCINAMIDE HYDROCHLORIDE)
101003 each Ask for price

Creatinine Assay Kit
abx098422-Hitachi7020R150ml3R250ml1 Hitachi 7020; R1: 50ml×3 R2: 50ml×1
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Creatinine Assay Kit
abx098422-Hitachi7060R190ml2R260ml1 Hitachi 7060; R1: 90ml×2 R2: 60ml×1
EUR 566.4

Creatinine Assay Kit
abx098422-Toshiba120R140ml3R240ml1 Toshiba 120; R1: 40ml×3 R2: 40ml×1
EUR 679.2

Creatinine Assay Kit
abx098422-Toshiba120R150ml3R250ml1 Toshiba 120; R1: 50ml×3 R2: 50ml×1
EUR 622.8

Creatinine Assay Kit
abx098422-Toshiba40R150ml3R250ml1 Toshiba 40; R1: 50ml×3 R2: 50ml×1
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Creatinine Assay Kit
55R-1467 100 assays
EUR 765.6
Description: Assay Kit for detection of Creatinine in the research laboratory

Creatinine ELISA Kit
DLR-Crtn-Ge-48T 48T
EUR 562.8
Description: A competitive inhibition quantitative ELISA assay kit for detection of Creatinine in samples from serum, plasma, tissue homogenates or other biological fluids.

Creatinine ELISA Kit
DLR-Crtn-Ge-96T 96T
EUR 729.6
Description: A competitive inhibition quantitative ELISA assay kit for detection of Creatinine in samples from serum, plasma, tissue homogenates or other biological fluids.

Creatinine Assay Kit
Z5030020 500 assays
EUR 636

Forodesine (hydrochloride)
HY-16209 2500ug
EUR 639.6

Creatinine N antibody
20-1373 100 ul
EUR 1054.8
Description: Sheep polyclonal Creatinine N antibody

Creatinine Standard, 1ML
C003-1ML 1ML
EUR 218

DOI hydrochloride
B5321-10 10 mg
EUR 205.2

DOI hydrochloride
B5321-5 5 mg
EUR 141.6

DOI hydrochloride
B5321-50 50 mg
EUR 714

DOB hydrochloride
B5344-1 1 mg
EUR 141.6

Q94 hydrochloride
B5705-10 10 mg
EUR 350.4

Q94 hydrochloride
B5705-50 50 mg
EUR 1264.8

GMQ hydrochloride
B5793-10 10 mg
EUR 212.4

GMQ hydrochloride
B5793-50 50 mg
EUR 711.6

AMT hydrochloride
B6480-10 10 mg
EUR 205.2

AMT hydrochloride
B6480-100 100 mg
EUR 1036.8

AMT hydrochloride
B6480-5 5 mg
EUR 141.6

AMT hydrochloride
B6480-50 50 mg
EUR 673.2

BEC (hydrochloride)
HY-19548A 25mg
EUR 570

EDC hydrochloride
GP0849-100G 100 g
EUR 141.6

EDC hydrochloride
GP0849-250G 250 g
EUR 237.6

EDC hydrochloride
GP0849-25G 25 g
EUR 84

EDC hydrochloride
GP0849-5G 5 g
EUR 55.2

SAG (hydrochloride)
HY-12848B 10mg
EUR 321.6

Creatinine (Cr) CLIA Kit
abx197924-96tests 96 tests
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Creatinine Acid antibody
20-1244 100 ul
EUR 651.6
Description: Sheep polyclonal Creatinine Acid antibody

Creatinine Standard, 100UL
C003-100UL 100UL
EUR 85

Creatinine Solution, 100ML
X116-100ML 100ML
EUR 94

Creatinine Solution, 25ML
X120-25ML 25ML
EUR 144

AMTB hydrochloride
B2978-25 25 mg
EUR 812.4

AMTB hydrochloride
B2978-5 5 mg
EUR 247.2

MPEP hydrochloride
B1151-10 each
EUR 222

MPEP hydrochloride
B1151-50 each
EUR 705.6

S1RA hydrochloride
B1180-10 10 mg
EUR 1144.8
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride
B1180-100 100 mg
EUR 4620
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride
B1180-5 5 mg
EUR 819.6
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride
B1180-5.1 10 mM (in 1mL DMSO)
EUR 895.2
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride
B1180-50 50 mg
EUR 3316.8
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

THZ1 Hydrochloride
B4736-10 10 mg
EUR 268.8
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

THZ1 Hydrochloride
B4736-25 25 mg
EUR 477.6
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

THZ1 Hydrochloride
B4736-5 5 mg
EUR 170.4
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

THZ1 Hydrochloride
B4736-5.1 10 mM (in 1mL DMSO)
EUR 205.2
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

EHNA hydrochloride
2265-25 each
EUR 339.6

EHNA hydrochloride
2265-5 each
EUR 138

TAME Hydrochloride
2050-100 each
EUR 151.2

TAME Hydrochloride
2050-1000 each
EUR 574.8

TAME Hydrochloride
2050-500 each
EUR 405.6

DMCM hydrochloride
B7268-10 10 mg
EUR 385.2

DMCM hydrochloride
B7268-100 100 mg
EUR 2210.4

DMCM hydrochloride
B7268-25 25 mg
EUR 776.4

DMCM hydrochloride
B7268-5 5 mg
EUR 277.2

DMCM hydrochloride
B7268-5.1 10 mM (in 1mL H2O)
EUR 297.6

DMCM hydrochloride
B7268-50 50 mg
EUR 1363.2

TRIS hydrochloride
B7299-500000 500 g
EUR 309.6

AMTB hydrochloride
B7559-10 10 mg
EUR 459.6

AMTB hydrochloride
B7559-50 50 mg
EUR 1746

MPEP Hydrochloride
A3633-10 10 mg
EUR 142.8
Description: IC50: 36 nMMPEP is a potent, selective and systemically active mGlu5 receptor antagonist. Metabotropic glutamate (mGlu) receptors are a of G-protein-coupled receptor family linked to multiple second messengers and modulation of ion channel functions in the nervous system.

MPEP Hydrochloride
A3633-50 50 mg
EUR 379.2
Description: IC50: 36 nMMPEP is a potent, selective and systemically active mGlu5 receptor antagonist. Metabotropic glutamate (mGlu) receptors are a of G-protein-coupled receptor family linked to multiple second messengers and modulation of ion channel functions in the nervous system.

MPTP hydrochloride
A3634-10 10 mg
EUR 162
Description: IC50 Value: 53uM?inhibited the nerve-evoked twitches of phrenic nerve-hemidiaphragm preparations from ICR mice? . MPTP HCl (Sigma-Chem.) induced reduction in the DOPAC HVA/dopamine (DA) ratio and increase in striatal ascorbate (AS) oxidation in rats [1].

MPTP hydrochloride
A3634-50 50 mg
EUR 344.4
Description: IC50 Value: 53uM?inhibited the nerve-evoked twitches of phrenic nerve-hemidiaphragm preparations from ICR mice? . MPTP HCl (Sigma-Chem.) induced reduction in the DOPAC HVA/dopamine (DA) ratio and increase in striatal ascorbate (AS) oxidation in rats [1].

MTEP hydrochloride
A3636-10 10 mg
EUR 205.2
Description: IC50: 5 nMMTEP is a selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonist.The mGluRs are classified into three groups: group I (mGluR1 and 5), group II (mGluR2 and 3) and group III (mGluR4, 6, 7 and 8).

MTEP hydrochloride
A3636-5 5 mg
EUR 153.6
Description: IC50: 5 nMMTEP is a selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonist.The mGluRs are classified into three groups: group I (mGluR1 and 5), group II (mGluR2 and 3) and group III (mGluR4, 6, 7 and 8).

MTEP hydrochloride
A3636-50 50 mg
EUR 686.4
Description: IC50: 5 nMMTEP is a selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonist.The mGluRs are classified into three groups: group I (mGluR1 and 5), group II (mGluR2 and 3) and group III (mGluR4, 6, 7 and 8).

PJ34 hydrochloride
A4159-10 10 mg
EUR 142.8
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride
A4159-5 5 mg
EUR 129.6
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride
A4159-5.1 10 mM (in 1mL DMSO)
EUR 150
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride
A4159-50 50 mg
EUR 296.4
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride
A4159-S Evaluation Sample
EUR 97.2
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

TCEP hydrochloride
B6055-10000 10 g
EUR 338.4
Description: Tris(2-carboxyethyl)phosphine hydrochloride (TCEP HCL) is a water soluble strong reducing agent that cleave disulfide bonds. It is a non-thiol and non-volatile solid.

TCEP hydrochloride
B6055-2000 2 g
EUR 150
Description: Tris(2-carboxyethyl)phosphine hydrochloride (TCEP HCL) is a water soluble strong reducing agent that cleave disulfide bonds. It is a non-thiol and non-volatile solid.

TCEP hydrochloride
B6055-50000 50 g
EUR 1243.2
Description: Tris(2-carboxyethyl)phosphine hydrochloride (TCEP HCL) is a water soluble strong reducing agent that cleave disulfide bonds. It is a non-thiol and non-volatile solid.

HEAT hydrochloride
B6339-10 10 mg
EUR 321.6

HEAT hydrochloride
B6339-50 50 mg
EUR 1167.6

THIP hydrochloride
B6460-100 100 mg
EUR 358.8

THIP hydrochloride
B6460-25 25 mg
EUR 174

THIP hydrochloride
B6460-50 50 mg
EUR 243.6

EHNA hydrochloride
B6662-10 10 mg
EUR 145.2

EHNA hydrochloride
B6662-25 25 mg
EUR 262.8

N20C hydrochloride
B6980-10 10 mg
EUR 340.8

N20C hydrochloride
B6980-50 50 mg
EUR 1245.6

TMPH hydrochloride
B7053-10 10 mg
EUR 321.6

TMPH hydrochloride
B7053-50 50 mg
EUR 1167.6

DAPI (hydrochloride)
C3362-10 10 mg
EUR 146.4

DAPI (hydrochloride)
C3362-25 25 mg
EUR 240

DAPI (hydrochloride)
C3362-5 5 mg
EUR 111.6

AD57 (hydrochloride)
C3080-1 1 mg
EUR 141.6
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer.

AD57 (hydrochloride)
C3080-10 10 mg
EUR 714
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer.

AD57 (hydrochloride)
C3080-5 5 mg
EUR 428.4
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer.

MMAD hydrochloride
ADC-P-019 unit Ask for price

MMAF Hydrochloride
ADC-P-021 unit Ask for price

THZ1 hydrochloride
9544-25 each
EUR 1227.6

THZ1 hydrochloride
9544-5 each
EUR 366

TRIS hydrochloride
GB4431-100G 100 g
EUR 64.8

TRIS hydrochloride
GB4431-1KG 1 kg
EUR 160.8

TRIS hydrochloride
GB4431-250G 250 g
EUR 76.8

TRIS hydrochloride
GB4431-500G 500 g
EUR 103.2

TRIS hydrochloride
GB4431-5KG 5 kg
EUR 486

EDAC, hydrochloride
EB0433 25g
EUR 123.68

TCEP (hydrochloride)
HY-W011500 10mM/1mL
EUR 135.6

MCLA hydrochloride
HY-W013275 5mg
EUR 381.6

DMCM (hydrochloride)
HY-100369A 100mg
EUR 1695.6

OABK (hydrochloride)
HY-100825 100mg
EUR 3531.6

EIPA (hydrochloride)
HY-101840A 10mM/1mL
EUR 151.2

Immunohistochemistry was attribute of AC myxoid tumor. After surgical procedure, pathologic evaluation confirmed this prognosis. The tumor confirmed no necrosis or invasion, had a low mitotic index (3/50 excessive energy fields) and Ki-67 proliferative index of 15%. In line with the completely different diagnostic techniques the tumor was categorized as an adenoma. In conclusion, the myxoid variant of AC tumors reveals peculiar cytologic options. If unaware of the existence of this variant, it could possibly simply be misinterpreted as a metastatic tumor.

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